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31.07.2011 PhAST equipment is being used for antimicrobial photodynamic assays

Researchers from the Universitat Politècnica de Catalunya are studying the microbial inactivation efficiency dependence on light dose delivered to the microorganisms by using different photosensitizers, in order to improve the understanding of photodynamic technique.

Antimicrobial photodynamic by using PhAST equipment

PhAST equipment is being used for antimicrobial photodynamic assays. Photodynamic activity of chemical compounds towards microorganisms was first published at the turn of 20th century, and it is based on the concept that a chemical compound, known as the photosensitizer, is localized preferentially in the microorganism and subsequently activated by low doses of visible light of an appropriate wavelength to generate reactive oxygen species that are toxic to the target microorganisms[Maisch 2009]. Researchers from the Universitat Politècnica de Catalunya are studying the microbial inactivation efficiency dependence on light dose delivered to the microorganisms by using different photosensitizers, in order to improve the understanding of photodynamic technique.

We are interested in driving the use of PhAST (blue, red, and yellow) as an ideal equipment to develop new photosensitizers and to perform in vitro assays especially in the microbial field. There is an urgent need for development of “smart” drugs that will overcome bacterial resistance, and PhAST could be an useful tool to achieve that.

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